Description

Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, gene expression, cell motility, cell division and cell death. The isoform alpha-1S (https://www.uniprot.org/#Isoform_alpha-1S) gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, and by benzothiazepines. Calcium channels containing the alpha-1S subunit play an important role in excitation-contraction coupling in skele|tal muscle (By similarity)