Description

The GABAA receptor is a crucial protein in the human brain that facilitates inhibitory neurotransmission, primarily by mediating the effects of the neurotransmitter GABA. It is a ligand-gated ion channel, meaning it opens in response to the binding of GABA, allowing chloride ions (Cl-) to enter the cell. This influx of negatively charged ions hyperpolarizes the neuron, effectively reducing its excitability. Description generated with AI. A printable model of the Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA plus diazepam. Two renderings are available - the complete assembled pentameric channel rendered as surface and individual subunits rendered as trace. Subunits can be assembled to form the complete channel. A close inspection shows the binding sites of GABA and diazepam, with the ligands represented as balls and sticks. Model generated from PDBID 6X3X (https://www.rcsb.org/structure/6X3X) with 3DP-Jmol (https://github.com/mariusmihasan/3DP-Jmol) - a Jmol/JSmol script that automatically generates 3D printable molecular models from structural data.