Description

Axin1 is a key protein involved in the regulation of canonical Wnt signaling and tumor suppression. It acts as a scaffold protein, facilitating the formation of the β-catenin destruction complex which inhibits Wnt signaling. Axin1 is a core component of the destruction complex, which targets β-catenin for degradation through phosphorylation and ubiquitination. By promoting β-catenin degradation, Axin1 inhibits the canonical Wnt pathway, which is a crucial pathway for cell growth and development. Axin1 interacts with other proteins involved in Wnt signaling, such as APC, GSK3β, and LRP5/6.