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Description
The KRAS protein acts as a molecular switch, regulating cell growth and division. It cycles between active (GTP-bound) and inactive (GDP-bound) states. oOncogenic mutations, can cause KRAS to become permanently stuck in the active state, leading to excessive signaling and uncontrolled cell growth. Mutated KRAS activates various downstream signaling pathways, including the RAF-MEK-ERK and PI3K-AKT-mTOR pathways, which promote cell proliferation, survival, and growth.
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- Source creator
- Jeff Miller
- Source license
- Public Domain
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