Description

Neutralizing antibodies targeting the peanut allergen Ara h 2 can effectively disrupt IgE-allergen interactions, preventing allergic reactions. These antibodies recognize specific epitopes on Ara h 2, creating potential use of these neutralizing antibodies to develop new treatments with oral immunotherapy for peanut allergies and other IgE-mediated food allergies. Molecule Name: Ara h 2 Source: Peanut Biological Role: Ara h 2 is a 2S albumin seed storage protein Associated Allergies: Peanut allergy, IgE-mediated food allergies Structural Notes: Epitopes identified that bind to the neutralizing antibodies consist of Ara h 2 residues #30-39 and #130-139. References & Links: PDB 8DB4, https://www.jci.org/articles/view/164501 Model 1: Surface model of peanut Ara h 2 protein with binding epitopes highlighted Model 2: Surface model of neutralizing antibodies with binding epitopes highlighted Model 3: Peanut Ara h 2 protein with two neutralizing antibodies Yellow - Ara h 2, Chain E Green - 13T1 Antibody heavy chain, Chain A Blue - 13T1 Antibody light chain, Chain B Pink - 22S1 Antibody heavy chain, Chain C Light Purple - 22S1 Antibody light chain, Chain D