Description

This is a molecular model of stereoisomerase NozR docked with substrate cyclo-L-Trp-L-Trp. NozR catalyzes the reversible interconversion of D/L stereoisomers of diketopiperazines (DKPs), including cyclo-L-Trp-L-Trp. NozR is an enzyme from the nocardioazine biosynthetic pathway from actinomycete Nocardiopsis sp. CMB-M0232. NozR and this molecular model were first published in: Deletti G, Green SD, Weber C, Patterson KN, Joshi SS, Khopade TM, Coban M, Veek-Wilson J, Caulfield T, Viswanathan R, Lane AL. (2023) Unveiling an indole alkaloid diketopiperazine biosynthetic pathway that features a unique stereoisomerase and multifunctional methyltransferase. Nature Communications . 14: 2558