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Description
Adagrasib (MRTX849) is an oral, small-molecule KRAS inhibitor developed by Mirati Therapeutics. KRAS mutations are highly common in cancer and account for approximately 85% of all RAS family mutations.
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- Source creator
- Antoine Simoneau
- Source license
- CC-BY
Archived copies are shared under the license shown.
View/download on NIH 3DTags
#nih-3d
#small molecules
#mrtx849
#adagrasib
#2326521-71-3
#mrtx-849
#krazati
#kras g12c inhibitor mrtx849
#8eoo6hqf8y
#adagrasib [usan]
#unii-8eoo6hqf8y
#2-((s)-4-(7-(8-chloronaphthalen-1-yl)-2-(((s)-1-methylpyrrolidin-2-yl)methoxy)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-yl)-1-(2-fluoroacryloyl)piperazin-2-yl)acetonitrile
#2-[(2s)-4-[7-(8-chloronaphthalen-1-yl)-2-[[(2s)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5h-pyrido[3,4-d]pyrimidin-4-yl]-1-(2-fluoroprop-2-enoyl)piperazin-2-yl]acetonitrile
#2-piperazineacetonitrile, 4-[7-(8-chloro-1-naphthalenyl)-5,6,7,8-tetrahydro-2-[[(2s)-1-methyl-2-pyrrolidinyl]methoxy]pyrido[3,4-d]pyrimidin-4-yl]-1-(2-fluoro-1-oxo-2-propen-1-yl)-, (2s)-
#2-piperazineacetonitrile, 4-(7-(8-chloro-1-naphthalenyl)-5,6,7,8-tetrahydro-2-(((2s)-1-methyl-2-pyrrolidinyl)methoxy)pyrido(3,4-d)pyrimidin-4-yl)-1-(2-fluoro-1-oxo-2-propen-1-yl)-, (2s)-
#compound 20 (pmid: 32250617)
#compound 20 [pmid: 32250617]
#2-[(2s)-4-[7-(8-chloronaphthalen-1-yl)-2-{[(2s)-1-methylpyrrolidin-2-yl]methoxy}-5h,6h,7h,8h-pyrido[3,4-d]pyrimidin-4-yl]-1-(2-fluoroprop-2-enoyl)piperazin-2-yl]acetonitrile
#mfcd32263433
#2-((s)-4-(7-(8-chloronaphthalen-1-yl)-2-(((s)-1-methylpyrrolidin-2-yl)methoxy)-5,6,7,8-tetrahydropyrido(3,4-d)pyrimidin-4-yl)-1-(2-fluoroacryloyl)piperazin-2-yl)acetonitrile
#2-[(2s)-4-[7-(8-chloronaphthalen-1-yl)-2-{[(2s)-1-methylpyrrolidin-2-yl]methoxy}-5h,6h,8h-pyrido[3,4-d]pyrimidin-4-yl]-1-(2-fluoroprop-2-enoyl)piperazin-2-yl]acetonitrile
#adagrasib [inn]
#mrtx849(adagrasib)?
#adagrasib [who-dd]
#mrtx 849
#chembl4594350
#schembl20974691
#gtpl10888
#dtxsid801336759
#bcp31538
#ex-a3258
#mrtx-849; mrtx 849
#bdbm50539763
#nsc831453
#s8884
#who 11519
#akos037648997
#at23561
#nsc-831453
#ac-35659
#bm177692
#bs-16211
#hy-130149
#cs-0105265
#a936721
#en300-26953032
#z4145344023
#((2s)-4-(7-(8-chloronaphthalen-1-yl)-2-(((2s)-1- methylpyrrolidin-2-yl)methoxy)-5,6,7,8- tetrahydropyrido(3,4-d)pyrimidin-4-yl)-1-(2-fluoroprop2-enoyl)piperazin-2-yl)acetonitrile
#((2s)-4-(7-(8-chloronaphthalen-1-yl)-2-(((2s)-1-methylpyrrolidin-2-yl)methoxy)-5,6,7,8-tetrahydropyrido(3,4-d)pyrimidin-4-yl)-1-(2-fluoroprop2-enoyl)piperazin-2-yl)acetonitrile
#[(2s)-4-[7-(8-chloro-1-naphthyl)-2-{[(2s)-1-methyl-2-pyrrolidinyl]methoxy}-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-yl]-1-(2-fluoroacryloyl)-2-piperazinyl]acetonitrile
#refchem:56312
#dtxcid001767019
#adagrasib (mrtx849)
#adagrasib [mi]
#krazati (tn)
#adagrasib (usan/inn)
#3mf
#blend
#fbx
#glb
#jpg
#mtl
#obj
#ply
#png
#stl
#wrl
#x3d
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