Description

These models are part of the collection for the NIH TB Portals program (https://tbportals.niaid.nih.gov). Arabinosyltransferases are involved in Mycobacterium tuberculosis cell wall synthesis and are targets for the anti-tuberculosis drug ethambutol. This structure is the B chain from PDB ID 7BVF and includes the bound drug. Sites with mutations associated with drug resistance have side chain atoms shown, with high frequency mutations indicated in magenta on the ribbon, and lower frequency mutations indicated in cyan on the ribbon. One of the models shows the surface surrounding the drug binding site.