Description

Vinorelbine (https://pubchem.ncbi.nlm.nih.gov/compound/Vinorelbine) is a semisynthetic vinca alkaloid. Vinorelbine (https://pubchem.ncbi.nlm.nih.gov/compound/Vinorelbine) binds to tubulin and prevents formation of the mitotic spindle, resulting in the arrest of tumor cell growth in metaphase. This agent may also interfere with amino acid, cyclic AMP (https://pubchem.ncbi.nlm.nih.gov/compound/cyclic%20AMP) . and glutathione (https://pubchem.ncbi.nlm.nih.gov/compound/glutathione) metabolism; calmodulin-dependent Ca++ -transport ATPase activity; cellular respiration; and nucleic acid and lipid biosynthesis.