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Description
Ixabepilone is a macrocycle that is a lactam analogue of epothilone B. Binds directly to beta-tubulin subunits on microtubules, leading to suppression of microtubule dynamics. It has a role as an antineoplastic agent and a microtubule-destabilising agent. It is a lactam, an epoxide, a member of 1,3-thiazoles, a macrocycle and a beta-hydroxy ketone.
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- Source creator
- Kzoghebi
- Source license
- CC-BY
Archived copies are shared under the license shown.
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#nih-3d
#small molecules
#ixabepilone
#azaepothilone b
#219989-84-1
#ixempra
#aza-epothilone b
#ixempra (tn)
#bms-247550
#bms 247550-1
#unii-k27005np0a
#ixabepilone (bms-247550)
#ixempra kit
#bms 247550-01
#nsc-747973
#chebi:63605
#bms-247550-01
#k27005np0a
#nsc747973
#bms 247550
#17-oxa-4-azabicyclo(14.1.0)heptadecane-5,9-dione, 7,11-dihydroxy-8,8,10,12,16-pentamethyl-3-((1e)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl)-, (1s,3s,7s,10r,11s,12s,16r)-
#1s,3s,7s,10r,11s,12s,16r)-7,11-dihydroxy-8,8,10,12,16-pentamethyl-3-((1e)-1-methyl-2-(2-methylthiazol-4-yl)ethenyl)-17-oxa-4-azabicyclo(14.1.0)heptadecane-5,9-dione
#ixabepilone [inn]
#(1~{s},3~{s},7~{s},10~{r},11~{s},12~{s},16~{r})-8,8,10,12,16-pentamethyl-3-[(~{e})-1-(2-methyl-1,3-thiazol-4-yl)prop-1-en-2-yl]-7,11-bis(oxidanyl)-17-oxa-4-azabicyclo[14.1.0]heptadecane-5,9-dione
#(1r,5s,6s,7r,10s,14s,16s)-6,10-dihydroxy-1,5,7,9,9-pentamethyl-14-((e)-1-(2-methyl-1,3-thiazol-4-yl)prop-1-en-2-yl)-17-oxa-13-azabicyclo(14.1.0)heptadecane-8,12-dione
#(1r,5s,6s,7r,10s,14s,16s)-6,10-dihydroxy-1,5,7,9,9-pentamethyl-14-[(e)-1-(2-methyl-1,3-thiazol-4-yl)prop-1-en-2-yl]-17-oxa-13-azabicyclo[14.1.0]heptadecane-8,12-dione
#ixempra (tm)
#16-aza-epothilone b
#ixabepilone [mi]
#ixabepilone [jan]
#ixabepilone [hsdb]
#ixabepilone [usan]
#ixabepilone [vandf]
#schembl8386
#ixabepilone [mart.]
#ixabepilone [usp-rs]
#ixabepilone [who-dd]
#ixabepilone (jan/usan/inn)
#ixabepilone [usan:inn:jan]
#gtpl6824
#schembl1890345
#chembl1201752
#chebi:95095
#hsdb 7738
#dtxsid70870252
#ixabepilone [orange book]
#ixabepilone [usp monograph]
#ex-a1245
#zinc3993846
#bdbm50564768
#mfcd04307791
#s7930
#akos025401600
#ccg-269752
#cs-0551
#db04845
#nsc 747973
#nsc-710428
#ncgc00378665-02
#ac-22618
#hy-10222
#d04645
#ab01273979-01
#989i841
#azaepothilone b;bms 247550;bms 247550-1
#sr-01000941577
#j-014409
#sr-01000941577-1
#q11711607
#(1r,5s,6s,7r,10s,14s,16s)-6,10-dihydroxy-1,5,7,9,9-pentamethyl-14-[[e]-1-(2-methyl-1,3-thiazol-4-yl]prop-1-en-2-yl)-17-oxa-13-azabicyclo(14,1,0)heptadecane-8,12-dione
#(1s,3s,7s,10r,11s,12s,16r)-7,11-dihydroxy-8,8,10,12,16-pentamethyl-3-[(1e)-1-(2-methyl-1,3-thiazol-4-yl)prop-1-en-2-yl]-17-oxa-4-azabicyclo[14.1.0]heptadecane-5,9-dione
#7-oxa-4-azabicyclo[14.1.0]heptadecane -5, 7,11-dihydroxy-8,8,10,12,16-pentamethyl-3-[(1e)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl]-, (1s,3s,7s,10r,11s,12s,16r)-
#gzx
#(1s,3s,7s,10r,11s,12s,16r)-7,11-dihydroxy-8,8,10,12,16-pentamethyl-3-((e)-1-(2-methylthiazol-4-yl)prop-1-en-2-yl)-17-oxa-4-azabicyclo[14.1.0]heptadecane-5,9-dione
#ixabepilona
#(1s,3s,7s,10r,11s,12s,16r)-7,11-dihydroxy-8,8,10,12,16-pentamethyl-3-[(e)-1-(2-methyl-1,3-thiazol-4-yl)prop-1-en-2-yl]-17-oxa-4-azabicyclo[14.1.0]heptadecane-5,9-dione
#ixabepilonum
#(1s,3s,7s,10r,11s,12s,16r)-7,11-dihydroxy-8,8,10,12,16-pentamethyl-3-((e)-1-(2-methyl-1,3-thiazol-4-yl)prop-1-en-2-yl)-17-oxa-4-azabicyclo(14.1.0)heptadecane-5,9-dione
#17-oxa-4-azabicyclo[14.1.0]heptadecane-5,9-dione, 7,11-dihydroxy-8,8,10,12,16-pentamethyl-3-[(1e)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl]-, (1s,3s,7s,10r,11s,12s,16r)-
#bms247550
#3mf
#blend
#fbx
#glb
#jpg
#mtl
#obj
#ply
#png
#stl
#wrl
#x3d
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