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Description
Dactinomycin is a chromopeptide antineoplastic antibiotic isolated from the bacterium Streptomyces parvulus. Dactinomycin intercalates between adjacent guanine (https://pubchem.ncbi.nlm.nih.gov/compound/guanine) - cytosine (https://pubchem.ncbi.nlm.nih.gov/compound/cytosine) base pairs, blocking the transcription of DNA by RNA polymerase; it also causes single-strand DNA breaks, possibly via a free-radical intermediate or an interaction with topoisomerase II.
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- Source creator
- Kzoghebi
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- CC-BY
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