Clofarabine
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Description

Clofarabine is a purine nucleoside analogue consisting of a 6-amino-2-chloropurin-9-yl group attached to the 1beta position of 2'-deoxy-2'-fluoro-D-arabinofuranose. It is metabolized intracellularly to the active 5'-triphosphate metabolite, which inhibits DNA synthesisis and so stops the growth of cancer cells. Clofarabine is used as an antimetabolite antineoplastic agent in the treatment of relapsed or refractory acute lymphoblastic leukaemia. It has a role as an antimetabolite and an antineoplastic agent. It is a member of adenosines and an organofluorine compound.

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Kzoghebi
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CC-BY
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#small molecules
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#(2r,3r,4s,5r)-5-(6-amino-2-chloropurin-9-yl)-4-fluoro-2-(hydroxymethyl)oxolan-3-ol
#2-chloro-9-(2-deoxy-2-fluoro-beta-d-arabinofuranosyl)-9h-purin-6-amine
#2-chloro-9-(2-deoxy-2-fluoro-beta-d-arabinofuranosyl)adenine
#chebi:681569
#(2r,3r,4s,5r)-5-(6-amino-2-chloro-9h-purin-9-yl)-4-fluoro-2-(hydroxymethyl)tetrahydrofuran-3-ol
#762rdy0y2h
#9h-purin-6-amine, 2-chloro-9-(2-deoxy-2-fluoro-beta-d-arabinofuranosyl)-
#(2r,3r,4s,5r)-5-(6-amino-2-chloro-9h-purin-9-yl)-4-fluoro-2-(hydroxymethyl)oxolan-3-ol
#nsc-759857
#2-chloro-9-(2'-deoxy-2'-fluoro-beta-d-arabinofuranosyl)adenine
#dsstox_cid_26437
#dsstox_rid_81613
#dsstox_gsid_46437
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#2-chloro-9-(2-deoxy-2-fluoro-b -d-arabinofuranosyl)-9h-purin-6-amine
#(2r,3r,4s,5r)-5-(6-amino-2-chloro-purin-9-yl)-4-fluoro-2-(hydroxymethyl)tetrahydrofuran-3-ol
#clolar (tn)
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#2-chloro-9-(2-deoxy-2-fluoro-beta-d-arabinofuranosyl)-adenine
#2-chloro-9-(2-deoxy-2-fluoro-?-d-arabinofuranosyl)-9h-purin-6-amine
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#9h-purin-6-amine, 2-chloro-9-(2-deoxy-2-fluoro-.beta.-d-arabinofuranosyl)
#(2r,3r,4s,5r)-5-(6-amino-2-chloropurin-9-yl)-4-fluoro-2-(hydroxymethyl)oxolan-3-ol 2-chloro-2''-arabino-fluoro-2''-deoxyadenosine
#en300-123437
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#dtxcid3026437
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#obj
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#png
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Clofarabine

From NIH 3D
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learning

License

CC-BY

Published

8/30/2026

Availability

free on NIH 3D