Cabozantinib
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Description

Cabozantinib is a dicarboxylic acid diamide that is N-phenyl-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide in which the hydrogen at position 4 on the phenyl ring is substituted by a (6,7-dimethoxyquinolin-4-yl)oxy group. A multi-tyrosine kinase inhibitor, used (as its malate salt) for the treatment of progressive, metastatic, medullary thyroid cancer. It has a role as an antineoplastic agent and a tyrosine kinase inhibitor. It is a member of quinolines, an aromatic ether, a dicarboxylic acid diamide and an organofluorine compound.

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Source creator
Kzoghebi
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CC-BY
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#nih-3d
#small molecules
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#849217-68-1
#cometriq
#xl-184
#xl184
#xl 184
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#n'-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]phenyl]-n-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide
#cabometyx (tn)
#cometriq (tn)
#1-n-[4-(6,7-dimethoxyquinolin-4-yl)oxyphenyl]-1-n'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide
#n-(4-((6,7-dimethoxy-4-quinolinyl)oxy)phenyl)-n'-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide
#1,1-cyclopropanedicarboxamide, n'-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]phenyl]-n-(4-fluorophenyl)-
#n-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]phenyl}-n'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide
#xl184 cpd
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#carbozantinib
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#xl184 free base
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#xl-184,cabozantinib, bms-907351
#ncgc00263164-01
#ncgc00263164-14
#ncgc00263164-17
#1,1-cyclopropanedicarboxamide,n-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]phenyl]-n'-(4-fluorophenyl)-
#ac-25082
#as-16277
#hy-13016
#n-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]phenyl}-n'-(4-fluorophenyl)cyclopropane-1,1- dicarboxamide
#sy097158
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#ft-0664184
#sw218093-3
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#sr-01000941569-1
#brd-k51544265-001-01-8
#1,1-cyclopropanedicarboxamide, n'-(4-((6,7-dimethoxy-4-quinolinyl)oxy]phenyl]-n-(4- fluorophenyl)-
#1,1-cyclopropanedicarboxamide, n-(4-((6,7-dimethoxy-4-quinolinyl)oxy)phenyl)-n'-(4-fluorophenyl)-
#cyclopropane-1,1-dicarboxylic acid [4-(6,7-dimethoxy-quinoline-4-yloxy)-phenyl]-amide(4-fluoro-phenyl)-amide
#cyclopropane-1,1-dicarboxylic acid[4-(6,7-dimethoxy-quinoline-4-yloxy)-phenyl]-amide (4-fluoro-phenyl)-amide
#n-(4-{[6,7-bis(methyloxy)quinolin-4-yl]oxy}phenyl)-n'-(4 fluorophenyl)cyclopropane-1,1-dicarboxamide
#n-(4-{[6,7-bis(methyloxy)quinolin-4-yl]oxy}phenyl)-n'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide
#n-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]phenyl]-n-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide
#n-[4-[(6,7-dimethoxyquinolin-4-yl)oxy]phenyl]-n inverted exclamation mark -(4-fluorophenyl)cyclopropane-1,1-dicarboxamide
#n-(4-((6,7-dimethoxyquinolin-4-yl)oxy)phenyl)-n-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide
#cabozantinibum
#n-(4-((6,7-dimethoxyquinolin-4-yl)oxy)phenyl)-n'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide
#refchem:57604
#dtxcid40156459
#l01xe26
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Cabozantinib

From NIH 3D
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learning

License

CC-BY

Published

9/14/2026

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free on NIH 3D