Description

Cabazitaxel is a semi-synthetic derivative of the natural taxoid 10-deacetylbaccatin III (https://pubchem.ncbi.nlm.nih.gov/compound/10-deacetylbaccatin%20III) with potential antineoplastic activity. Cabazitaxel binds to and stabilizes tubulin, resulting in the inhibition of microtubule depolymerization and cell division, cell cycle arrest in the G2/M phase, and the inhibition of tumor cell proliferation. Unlike other taxane (https://pubchem.ncbi.nlm.nih.gov/compound/taxane) compounds, this agent is a poor substrate for the membrane-associated, multidrug resistance (MDR), P-glycoprotein (P-gp) efflux pump and may be useful for treating multidrug-resistant tumors. In addition, cabazitaxel penetrates the blood-brain barrier (BBB).