Description

Triacsins are a family of natural products containing an N‐hydroxytriazene moiety not found in any other known secondary metabolites. Triacsin C is a potent inhibitor of long fatty acyl CoA synthetase. It blocks β-cell apoptosis, induced by fatty acids in a rat model of obesity. In addition, it blocks the de novo synthesis of triglycerides, diglycerides, and cholesterol esters, thus interfering with lipid metabolism. https://doi.org/10.1002/cbic.201800762