Find3DModelsFind your next model

Bms-214662

Click to view full size

Preview 1

Description

BMS-214662 is a member of the class of benzodiazepines that is 2,3,4,5-tetrahydro-1H-1,4-benzodiazepine substituted by (1H-imidazol-5-yl)methyl, benzyl, (thiophen-2-yl)sulfonyl, and cyano groups at positions 1, 3R, 4 and 7, respectively. It is a potent inhibitor of farnesyltransferase (IC50 = 1.35nM) which was under clinical development for the treatment of solid tumors. It has a role as an antineoplastic agent, an EC 2.5.1.58 (protein farnesyltransferase) inhibitor and an apoptosis inducer. It is a nitrile, a member of benzenes, a benzodiazepine, a member of imidazoles, a member of thiophenes and a sulfonamide.

From NIH 3D

Model source and downloads

This page preserves searchable metadata and attribution. Use NIH 3D for the current files and source details.

Source creator: alex.sigaras
Source license: CC-BY

Archived copies are shared under the license shown.

View/download on NIH 3D

Tags

#small molecules

#unii-l2u9gfd244

#(r)-1-((1h-imidazol-5-yl)methyl)-3-benzyl-4-(thiophen-2-ylsulfonyl)-2,3,4,5-tetrahydro-1h-benzo[e][1,4]diazepine-7-carbonitrile

#olcwflwehwlbto-hszrjfapsa-n

#3-benzyl-1-(1h-imidazol-4-ylmethyl)-4-(thien-2-ylsulfonyl)-2,3,4,5-tetrahydro-1h-1,4-benzodiazepine-7-carbonitrile

#(3r)-3-benzyl-1-(1h-imidazol-5-ylmethyl)-4-thiophen-2-ylsulfonyl-3,5-dihydro-2h-1,4-benzodiazepine-7-carbonitrile

#(r)-2,3,4,5-tetrahydro-1-(1h-imidazol-4-ylmethyl)-3-(phenylmethyl)-4-(2-thienylsulfonyl)-1h-1,4-benzodiazepine-7-carbonitrile

#7-cyano-2,3,4,5-tetrahydro-1-(1h-imidazol-4-ylmethyl)-3-(phenylmethyl)-4-(2-thienylsulfonyl)-1h-1,4-benzodiazepine

#dtxsid20173260

#bms 214662 [who-dd]

#(3r)-1-(3h-imidazol-4-ylmethyl)-3-(phenylmethyl)-4-thiophen-2-ylsulfonyl-3,5-dihydro-2h-1,4-benzodiazepine-7-carbonitrile

#(3r)-1-(4-imidazolylmethyl)-3beta-benzyl-4-(2-thienylsulfonyl)-2,3,4,5-tetrahydro-1h-1,4-benzodiazepine-7-carbonitrile

#(3r)-3-benzyl-1-(1h-imidazol-4-ylmethyl)-4-(thiophen-2-ylsulfonyl)-2,3,4,5-tetrahydro-1h-1,4-benzodiazepine-7-carbonitrile

#(3r)-3-benzyl-1-(1h-imidazol-5-ylmethyl)-4-(thiophen-2-ylsulfonyl)-2,3,4,5-tetrahydro-1h-1,4-benzodiazepine-7-carbonitrile

#(r)-2,3,4,5-tetrahydro-1-(1h-imidazol-4-ylmethyl)-3-(phenylmethyl)-4-(2-thienyisulfonyl)-1h-1,4-benzodiazepine-7-carbonitile

#(r)-3-benzyl-1-(1h-imidazol-4-ylmethyl)-4-(thiophene-2-sulfonyl)-2,3,4,5-tetrahydro-1h-benzo[e][1,4]diazepine-7-carbonitrile

#(r)-3-benzyl-1-(3h-imidazol-4-ylmethyl)-4-(thiophene-2-sulfonyl)-2,3,4,5-tetrahydro-1h-benzo[e][1,4]diazepine-7-carbonitrile

#(r)-7-cyano-2,3,4,5-tetrahydro-1-(1h-imidazol-4-ylmethyl)-3-(phenylmethyl)-4-(2-thienylsulfonyl)-1h-1,4-benzodiazepine

#1h-1,4-benzodiazepine-7-carbonitrile, 2,3,4,5-tetrahydro-1-(1h-imidazol-4-ylmethyl)-3-(phenylmethyl)-4-(2-thienylsulfonyl)-, (3r)-

#1h-1,4-benzodiazepine-7-carbonitrile, 2,3,4,5-tetrahydro-1-(1h-imidazol-4-ylmethyl)-3-(phenylmethyl)-4-(2-thienylsulfonyl)-, (r)-

#3-benzyl-1-(3h-imidazol-4-ylmethyl)-4-(thiophene-2-sulfonyl)-2,3,4,5-tetrahydro-1h-benzo[e][1,4]diazepine-7-carbonitrile

#refchem:120710

#fti bms 214662

#(3r)-3-benzyl-1-(1h-imidazol-5-ylmethyl)-4-(thiophene-2-sulfonyl)-2,3,4,5-tetrahydro-1h-1,4-benzodiazepine-7-carbonitrile

Makes

See how others have printed this model

Comments

Share your thoughts and ask questions

Sign in to join the conversation

Bms-214662

From NIH 3D

Likes

0

Views

0

Remixes

0

Category

License

CC-BY

Published

8/30/2026

Availability

free on NIH 3D