Description

7-Aminomethyl-7-carbaguanine (https://pubchem.ncbi.nlm.nih.gov/compound/7-Aminomethyl-7-carbaguanine) is one of the precursors of nucleoside Q (https://pubchem.ncbi.nlm.nih.gov/compound/nucleoside%20Q) (queuosine (https://pubchem.ncbi.nlm.nih.gov/compound/queuosine)) biosynthesis. It is a substrate for preQ1 (https://pubchem.ncbi.nlm.nih.gov/compound/preQ1) synthase (EC 1. 7. 1. 13) which catalyzes the NADPH (https://pubchem.ncbi.nlm.nih.gov/compound/NADPH)-dependent reduction of 7-cyano-7-carbaguanine (https://pubchem.ncbi.nlm.nih.gov/compound/7-cyano-7-carbaguanine) (preQ0 (https://pubchem.ncbi.nlm.nih.gov/compound/preQ0)) to 7-aminomethyl-7-carbaguanine (https://pubchem.ncbi.nlm.nih.gov/compound/7-aminomethyl-7-carbaguanine) (preQ1 (https://pubchem.ncbi.nlm.nih.gov/compound/preQ1)). More specifically, this enzyme catalyzes the chemical reaction. 7-aminomethyl-7-carbaguanine (https://pubchem.ncbi.nlm.nih.gov/compound/7-aminomethyl-7-carbaguanine) + 2 NADP+ (https://pubchem.ncbi.nlm.nih.gov/compound/NADP%2B) 7-cyano-7-carbaguanine (https://pubchem.ncbi.nlm.nih.gov/compound/7-cyano-7-carbaguanine) + 2 NADPH (https://pubchem.ncbi.nlm.nih.gov/compound/NADPH) + 2 H+.