Monomethyl Fumarate
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Description

Monomethyl fumarate is a dicarboxylic acid monoester resulting from the formal condensation of one of the carboxy groups of fumaric acid with methanol. Is is a metabolite of dimethyl fumarate and used for the the treatment of patients with relapsing multiple sclerosis (MS). It also induces the NFE2L2 (Nrf2) transcription factor by binding to KEAP1. It has a role as an antioxidant, a drug metabolite and an immunomodulator. It is a methyl ester, a dicarboxylic acid monoester and an enoate ester. It is functionally related to a fumaric acid.

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znnx2010
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Public Domain
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#(2e)-4-methoxy-4-oxo-2-butenoic acid #
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Monomethyl Fumarate

From NIH 3D
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Category

learning

License

CC0

Published

9/1/2026

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free on NIH 3D