Donepezil
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Description

Donepezil is a racemate comprising equimolar amounts of (R)- and (S)-donepezil. A centrally acting reversible acetylcholinesterase inhibitor, its main therapeutic use is in the treatment of Alzheimer's disease where it is used to increase cortical acetylcholine. It has a role as an EC 3.1.1.8 (cholinesterase) inhibitor, an EC 3.1.1.7 (acetylcholinesterase) inhibitor and a nootropic agent. It contains a (S)-donepezil and a (R)-donepezil. It is a conjugate base of a donepezil (1+).

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Source creator
Meghan McCarthy
Source license
Public Domain
Archived copies are shared under the license shown.
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#nih-3d
#small molecules
#donepezil
#120014-06-4
#eranz
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#donepezil [inn:ban]
#donepezil (inn)
#donaz (tn)
#chebi:53289
#2-((1-benzylpiperidin-4-yl)methyl)-5,6-dimethoxy-2,3-dihydro-1h-inden-1-one
#aricept
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#2-[(1-benzyl-4-piperidyl)methyl]-5,6-dimethoxy-2,3-dihydroinden-1-one
#2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2,3-dihydro-1h-inden-1-one
#hsdb 7743
#142057-79-2
#chembl502
#(s)-e2020 (free base)
#8ssc91326p
#2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2,3-dihydroinden-1-one
#donepezil [inn]
#d-797
#1h-inden-1-one, 2,3-dihydro-5,6-dimethoxy-2-((1-(phenylmethyl)-4-piperidinyl)methyl)-
#142057-80-5
#(rs)-2-[(1-benzyl-4-piperidyl)methyl]-5,6-dimethoxyindan-1-one
#1h-inden-1-one, 2,3-dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-
#2,3-dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-1h-inden-1-one
#nsc 737535
#nsc 758882
#ncgc00167537-01
#domepezil
#unii-8ssc91326p
#2-((1-benzyl-4-piperidyl)methyl)-5,6-dimethoxy-2,3-dihydroinden-1-one
#2,3-dihydro-5,6-dimethoxy-2-((1-(phenylmethyl)-4-piperidinyl)methyl)-1h-inden-1-one
#spectrum_001664
#donepezil [jan]
#donepezil [mi]
#donepezil [hsdb]
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#donepezil [vandf]
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#d797
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#ab00640013-07
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#2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxyindan-1-one
#(+/-)-2-((1-benzyl-4-piperidyl)methyl)-5,6-dimethoxy-1-indanone
#(+/-)-2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-indan-1-one
#2-[(1-benzyl-4-piperidyl)methyl]- 5,6-dimethoxy-2,3-dihydroinden-1-one
#2,3-dihydro-5,6-dimethoxy-2 [[1-(phenyl methyl)-4-piperidinyl]methyl]-1h-inden-1-one
#2,3-dihydro-5,6-dimethoxy-2[[1-(phenyl methyl)-4-piperidinyl]methyl]-1h-inden-1-one
#5,6-dimethoxy-2-[[1-(phenylmethyl)piperidin-4-yl]methyl]-2,3-dihydroinden-1-one
#5,6-dimethoxy-2-((1-(phenylmethyl)-4-piperidinyl)methyl)-2,3-dihydro-1h-inden-1-one
#en300-267872
#donezpil hydrochloride
#5,6-dimethoxy-2-((1-(phenylmethyl)piperidin-4-yl)methyl)-2,3-dihydroinden-1-one
#donepezil hydrochlorid
#refchem:5777
#dtxcid0028292
#n06da02
#3mf
#blend
#fbx
#glb
#jpg
#mtl
#obj
#ply
#png
#stl
#wrl
#x3d

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Donepezil

From NIH 3D
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Category

learning

License

CC0

Published

10/15/2026

Availability

free on NIH 3D